Ciliary Dyskinesia in Bobtail

Ciliary Dyskinesia leads to respiratory problems. About 17% of English Ancestral Sheepdogs (Bobtail) carry the genetic mutation responsible for this disease. A reliable DNA test can be used to detect breeders, to adapt mating to avoid breeding puppies and to propagate the disease in the breed.

A serious inherited disease

Dyskinesia Ciliary leads to chronic respiratory problems. The first symptoms are associated from an early age to infections of the respiratory mucosa (nose, trachea, bronchi) that result in sneezing, a cough and chronic chronic bronchitis. Even if the disease is treated early, the symptoms get worse and the dog is usually euthanized

Frequent disease

About 17% of the Bobtail in Europe carry the genetic mutation responsible for Ciliary Dyskinesia. A breeder can unknowingly mate a male carrier and a female carrier and breed litter with infected puppies.
A breeding dog that is a healthy carrier does not develop the disease but transmits it to 50% of its offspring. A mutation-bred stallion, which reproduces a lot, then spreads the disease within the breed and helps to increase the frequency of the mutation and increase the number of pups reached.

A preventable disease

When that a dog is affected by the disease, this means that both parents are healthy carriers (affected dogs are not fertile). Breeders who are not sensitized to Ciliary Dyskinesia can unknowingly mate with the breeders carrying the mutation and give birth to infected puppies.
A DNA test, called a PCD test (for Primary Ciliary Dyskinesia), makes it possible to detect Ciliary Dyskinesia. du Bobtail with a reliability greater than 99%

To avoid breeding puppies

The breeder to secure his breeding and not to take the risk of breeding puppies must absolutely detect his breeding stock DNA test aid
When acquiring a puppy for breeding or when using a stallion for a breeding, the breeder checks the dog's genetic status for Ciliary Dyskinesia by asking for the result of the DNA test

A DNA test easy to carry out

The vet carries out a simple oral swab that is sent to the laboratory. The result, delivered in a few days, indicates whether the tested dog is healthy, healthy carrier or has Ciliary Dyskinesia. The result in the form of a genetic certificate must be used as a guarantee in the context of a breeding or to justify the sale of ciliary dyskinesia free puppies.
The veterinarian who prematurely observes respiratory problems in a young person Bobtail may implement the DNA test to confirm or disprove the diagnosis of Ciliary Dyskinesia. If the dog is actually affected, the parents must also be tested.
Breeders who know the genetic status of their dogs can select breeders, adapt mating, avoid breeding puppies and limit the spread of this serious respiratory disease in the breed.
Dr Guillaume QUENEY
Laboratory ANTAGENE

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